Plus, each serving of barley grass contains a good amount of vitamin A, a fat-soluble vitamin that regulates immune function, cell growth, and vision (2). Small conductance Ca2+-activated K+ channels not only expressed in the paraventricular nucleus play a key role in the regulation of arterial blood pressure and cardiovascular function [140], but also inhibited lots of situations of atrial fibrillation in the heart under normal and pathophysiological conditions [164]. The data summarized in current review point out that major mechanism and more than 30 functional ingredients of barley grass exert potent preventive exceed 20 chronic diseases. The effective foods of improving sleep for modern people are polished rice or wheat flour plus BG powder and its products [70]. Barley grass may also have the potential to fight cancer. Kuge T., Nagoya H., Tryfona T., et al. Barley grass was shown in the study to induce apoptosis in cancer cell-lines of breast and prostate cancer by increasing the reactive oxygen species (ROS) levels. Hoffmann M. R., Senior P. A., Mager D. R. Vitamin D supplementation and health-related quality of life: a systematic review of the literature. 1500 E. Medical Center Drive Room 5316 CC. Antioxidants are plant compounds that help prevent free radical damage to your cells. Gui L., LaGrange L. P., Larson R. A., Gu M., Zhu J., Chen Q. H. Role of small conductance calcium-activated potassium channels expressed in PVN in regulating sympathetic nerve activity and arterial blood pressure in rats. Saponarin from barley sprouts is a very important functional ingredient of natural anti-inflammation [106]. Higher dietary flavonoid intake associated with gastric cancer risk decreased in European population [32]. The authors declare that they have no conflicts of interest whatsoever to declare. Park M. J., Seo W. D., Kang Y.-H. Barley grass reduces blood uric acid, which has lots of benefits on feces metabolism, lipids metabolism, liver function, and antioxidant system for human [120]. Lastly, its rich in polyphenols and flavonoids. However, its effect on cancer cells is yet to be clearly defined. Effect of two drying methods on the quality of barley grass powder. Barley grass extract causes apoptosis of cancer cells by increasing intracellular reactive oxygen species production Biomed Rep. 2017 Jun;6 (6):681-685. doi: 10.3892/br.2017.897. Ann Arbor, MI 48109. Impairment of IKCa channels contributes to uteroplacental endothelial dysfunction in rat diabetic pregnancy. [. Pure Barley grass is a powerful antioxidant that is believed to help the body kill cancer cells and overcome a variety of ailments. Choi S. W., Kim S. H., Lee K. S., et al. The total phenolic content is 26.55mg/100g on 23 days after the sowing, but 13.91mg/100g on 56 days for BG, which are major hydroxycinnamic acid, orientin, isoorientin, and isovitexin derivatives [39]. BG can prevent thrombosis and cardiovascular diseases by enhancing better blood viscosity and flow [125]. Choe J.-H., Choi J.-H., Choi Y.-S., et al. Regular consumption of barley has 8000 years history, which may become a successful and safe strategy to treat chronic disease conditions. Jiang Q. Gao T., Zhang M., Han Y., Huang S. B. Role of bifunctional ammonia-lyase in grass cell wall biosynthesis. 1 box 60 capsules Sante Barley Powder in Vegetable Capsules Sant Barley is a 500-mg pure barley grass powder packed in vegetable Being rich in vitamins and minerals for the daily diet needed by the human body, Sant Barley Max helps middle-aged, health-conscious individuals enjoy a good quality of life. The barley seedling (1g/mL) has significant effect on anti-fatigue in mice, especially the exhausting swimming and antianoxic time with significant longer, which reduced blood glucose significantly of diabetes inducted by alloxan (C4H4N2O5) and gastric ulcer induced by alcohol [128]. Research progress of nutritional and health function of barley leaves powder. All rights reserved. BG and its extract can scavenge oxygen free radicals, improve health, based on protective vascular diseases, and impair the pancreas endocrine of diabetic patients [72, 73]; its dietary fiber has a significant reduction in fasting blood sugar and blood glucose [74]. Superoxide dismutase, which is also known to fight free radicals, may help protect the body from the cancer-causing effects of radiation. Kitta K., Hagiwara Y., Shibamoto T. Antioxidative activity of an isoflavonoid, 2-O-glycosylisovitexin isolated from green barley leaves. Add ingredients to a blender and blend until smooth. Epub 2017 May 3. Youssef H. M., Eggert K., Koppolu R., et al. Feeds supplemented with barley leaves containing antioxidants enhanced pork quality by increasing the levels of unsaturated oleic and gondoic acids [117]. . The following nutritional data is from the USDA. In cancer, Bex has been revealed to inhibit tumor growth. Yunnan province has the lowest cancer mortality and is the largest producer of anticancer barley, but Shanghai in China has the highest cancer mortality, which is associated with the sharp decline of barley [104]. Strategies of functional foods promote sleep in human being. Barley seedling extracts inhibited RANKL-induced osteoclast differentiation with alteration of IB degradation, c-Fos, and NFATc1 molecules in osteoclastogenesis [134]. The phytochemical combinations of barley might be helpful against breast cancer. Antioxidant enzymes in BG include SOD, CAT, POD, APX, lipid peroxidation, protein oxidation, DNase activity, and DNA damage, which are oxidative biomarkers in response to Al3+ stress [44]. Functional ingredients of barley grass for therapeutic chronic disease. Zeng Y. W., Du J., Yang X. M., et al. Therefore, more high quality studies should be conducted to better examine how consuming barley grass may affect heart health in humans. Vitamins can treat nonalcoholic steatohepatitis (VE) and chronic hepatitis C virus (VB12 and VD), reduce gallstones (VC), aphthous stomatitis (VB12), and inflammatory bowel disease (VD and VB1), and so on [64]. In spray-dried barley grass powder with good solubility and small size, its contents of the chlorophyll, flavonoids, and SOD enzyme activity are 56.7%, 68.1%, and 47.9% of vacuum freeze-dried powder with high nutrition and good color, respectively [18]. BG of Yungong brand has also lustihood, bone injury recovery, antiaging, losing weight, reducing blood fat [10]. The accumulation of lutonarin (isoorientin-7-O-glucoside) and 3-feruloylquinic acid (C17H20O9) and xanthophyll-cycle pigments is greatly increased by high photosynthetically active radiation and ultraviolet exposure in barley leaves [9]. The erythrocyte zinc and SOD activity are influenced by metabolic syndrome, plasmatic glucose, body mass index, and waist circumference [46]. Schiller M., Hegelund J. N., Pedas P., et al. Barley grass is rich in vitamins and minerals, has antioxidant properties, and has been shown to reduce cholesterol levels. Jiang X. L., Li M., Zhou J. G., Yang Q. Bubko I., Gruber B. M., Anuszewska E. L. The role of thiamine in neurodegenerative diseases. Barley leaves extracted by methanol and ethanol may be alternatives to synthetic antioxidants in the food industry [114]. Gokina N. I., Bonev A. D., Phillips J., et al. The amino acid and vitamin C content in hydroponic BG are higher than those in organic soil [17]. Therapeutic role of functional components in Alliums for preventive chronic disease in human being. The total flavonoid contents in BG increased from 273.1 to 515.3CE mg/100g between 13 and 56 days after sprouting; however, lutonarin (isoorientin-7-O-glucoside) has stronger radical scavenging activity than saponarin (isovitexin-7-O-glucoside); its antioxidant ability is improved with growth time, which exhibited high total polyphenol (44.3755.07%) [13]. Effects of barley green on serum lipid, MDA, SOD, ET-1 and NO of hyperlipoproteinemia rats. Barley is a cereal grain. Nevertheless, studies on the effects of barley grass specifically are limited, and many are outdated. Seo W. D., Lee J. H., Jia Y., Wu C., Lee S. J. Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5. van Dalfsen J. H., Markus C. R. Interaction between 5-HTTLPR genotype and cognitive stress vulnerability on sleep quality: effects of sub-chronic tryptophan administration. Xin P. Y., Pu X. Y., Du J., Yang T., Zeng Y. W. Protein content determination of barley grain and seedling powder. Preparation of two flavonoid glycosides with unique structures from barley seedlings by membrane separation technology and preparative high-performance liquid chromatography. 6. Idehen E., Tang Y., Sang S. Bioactive phytochemicals in barley. Effect of, Gul S., Ahmed S., Kifli N., et al. Nutrition, Benefits and How to Cook It. Saponarin from barley sprouts inhibits NF-. Miura S., Yoshihisa A., Takiguchi M., et al. Elucidation of phenolic antioxidants in barley seedlings (Hordeum vulgare L.) by UPLC-PDA-ESI/MS and screening for their contents at different harvest times. Anti-aging properties. 500 polyphenols are distributed across a wide variety of foods; a protective role of dietary polyphenols against chronic diseases includes preventing cardiovascular diseases, diabetes, and cancer [66], due to their antioxidant and anti-inflammatory properties, and improving blood pressure and lipids as well as insulin resistance, which may reduce the risk of all-cause mortality [67]. Richter A., Peter E., Prs Y., Lorenzen S., Grimm B., Czarnecki O. 31260326), and the Science and Technology to Benefit the People (2014RA060) and Natural Science Foundation (no. Ingredients 1 1/2 tsp barley grass juice powder 6 oz water 2 oz OJ, apple juice or your favorite juice Instructions Green barley extract has anticancer effect by its antiproliferative and proapoptotic functions on leukemia and lymphoma as well as breast cancer cells of human beings [102]. There are greater differences of saponarin and lutonarin contents in barley leaves at the growth stage; in particular, its lutonarin content at shooting period is 6.4 times higher than that at one leaf period, and its saponarin content in two leaves at one period is 6.5 times higher than that at heading period [11]. Barley is among the most stress-tolerant crops, its flag leaf -tocopherol, glutathione and succinate content by same genes encoding enzymes of the pathways producing antioxidant metabolites [111]. Antioxidants L-carnitine (C7H15NO3) and d-methionine (C5H11NO2S) regulate cortical electrical spike activity through GABAA receptor activation [147]; GABAB receptor positive allosteric modulators are very important in the treatment of alcoholism [153]. Farajnia S., Meijer J. H., Michel S. Age-related changes in large-conductance calcium-activated potassium channels in mammalian circadian clock neurons. The amino acid concentration in barley grass irradiated by artificial light (red 9+blue 1) is greater than that by natural light, which can increase -tocopherol by 100% red light [7], but cyanogenic glucosides content is 4% less than that by sunlight [8]. Klem K., Holub P., troch M., et al. Thaiss C. A., Itav S., Rothschild D., et al. Heres a simple recipe for a barley grass smoothie: Barley grass powder is widely available and can be added to a variety of juices, smoothies, and shakes. Duan Q.-H., Li Y., Ge Z.-X., et al. 5. Promotes sleep Barley grass powder with high tryptophan, potassium, calcium and GABA content can aid in promoting good sleep. Gmez-Marcos A., Blzquez-Medela A. M., Gamella-Pozuelo L., Recio-Rodriguez J. I., Garca-Ortiz L., Martnez-Salgado C. Serum superoxide dismutase is associated with vascular structure and function in hypertensive and diabetic patients. Lee Y. J., Wang M. Y., Lin M. C., Lin P. T. Associations between vitamin B-12 status and oxidative stress and inflammation in diabetic vegetarians and omnivores. Photosystem II core dimers began to dissociate monomers at 4050C for heated (1C/min) barley leaves, and chlorophyll-containing protein complexes appeared at 5760C [56]. An increase in K+ intake can prevent heart disease which associate with decreasing inflammation and oxidative stress [10, 50]. Barley grass is a common ingredient often featured in juices, supplements, and greens powders. Song H., Xu X., Wang H., Wang H., Tao Y. Exogenous gamma-aminobutyric acid alleviates oxidative damage caused by aluminium and proton stresses on barley seedlings. Wheat flour plus BG powder and its products [ 70 barley grass powder cancer technology and preparative high-performance liquid chromatography risk. Tryptophan, potassium, calcium and GABA content can aid in promoting good sleep in being! 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Grimm B., Czarnecki O consuming barley grass for therapeutic chronic disease and safe strategy treat! Antioxidative activity of an isoflavonoid, 2-O-glycosylisovitexin isolated from green barley leaves levels of unsaturated oleic and gondoic [!

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