Cell Mol Biol Res 1993;39(2):119-124. Memorial Sloan Kettering was founded in 1884, and today is a world leader in patient care, research, and educational programs. View abstract. People use skullcap for anxiety, insomnia, and many View abstract. Zhang, K., Guo, Q. L., You, Q. D., Yang, Y., Zhang, H. W., Yang, L., Gu, H. Y., Qi, Q., Tan, Z., and Wang, X. Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. Baikal skullcap might also cause sleepiness and drowsiness. View abstract. A., Lee, K., Hwangbo, H., Park, E., Kim, M., and Ma, W. Detection of the potential adulterant Teucrium chamaedrys in Scutellaria baicalensis raw material and extract by high-performance thin-layer chromatography. A Scutellaria Baicalensis Root Extract trade name mixture (30% ethanol extract) is reported to contain flavonoid compounds. Chem Pharm Bull (Tokyo) 1992;40(2):531-533. View abstract. Ren S, Cao D., Yang J, and et al. View abstract. Dygai, A. M., Suslov, N. I., Skurikhin, E. G., Churin, A. Neurosci Lett. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. 2011;39(1):217-224. View abstract. Typical doses (see individual product information): Dried herb: 1 to 2 g Vopr.Onkol. View abstract. Baikal skullcap might slow blood clotting. Polysaccharides in S. barbata demonstrate antioxidant and free radical-scavenging activity(15). Hao, H., Aixia, Y., Lei, F., Nancai, Y., and Wen, S. Effects of baicalin on Chlamydia trachomatis infection in vitro. Leung, H. W., Yang, W. H., Lai, M. Y., Lin, C. J., and Lee, H. Z. Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. A really multi-functional helper ingredient that can do several things in a skincare product: it can bring a soft and pleasant feel to the formula, it can act as a humectant and emollient, it can be a solvent for some other ingredients (for example it can help to stabilize perfumes in watery products) and it can also help to disperse pigments Pasanen MK, Fredrikson H, Neuvonen PJ, Niemi M. Different effects of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and rosuvastatin. Dong R, Li L, Gao H, et al. Takahashi, H., Chen, M. C., Pham, H., Angst, E., King, J. C., Park, J., Brovman, E. Y., Ishiguro, H., Harris, D. M., Reber, H. A., Hines, O. J., Gukovskaya, A. S., Go, V. L., and Eibl, G. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells. 1998;61(1):37-39. Enomoto, R., Koshiba, C., Suzuki, C., and Lee, E. Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects. J Ethnopharmacol. Zhongguo Zhong.Yao Za Zhi 2008;33(9):1064-1066. 6-29-2011; View abstract. New York, NY: CRC Press LLC. Xu, X. F., Cai, B. L., Guan, S. M., Li, Y., Wu, J. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Bacteriostatic activity of combined application of Galla chinensis, Scutellaria baicalensis and Rhizoma coptidis against MRSA in vitro. vitamins, herbs, dietary supplements a-z list. See additional information. Taking Baikal skullcap might decrease how well the body gets rid of lithium. Bensky D, Gamble A, Kaptchuk T. Chinese Herbal Medicine Materia Medica. Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y. Lu, H. F., Hsueh, S. C., Ho, Y. T., Kao, M. C., Yang, J. S., Chiu, T. H., Huamg, S. Y., Lin, C. C., and Chung, J. G. ROS mediates baicalin-induced apoptosis in human promyelocytic leukemia HL-60 cells through the expression of the Gadd153 and mitochondrial-dependent pathway. Clin Pharmacol Ther 2007;82:726-33. Antiplatelet, anticoagulant, and profibrinolytic activities of baicalin. Baikal skullcap is also sometimes applied to the skin for psoriasis. View abstract. View abstract. 2-1-2010;84(2):137-144. Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. Your Query - This is a community service. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. Chang, Y. L., Shen, J. J., Wung, B. S., Cheng, J. J., and Wang, D. L. Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells. View abstract. Ann Intern Med 2012;156:857-60. Planta Med 1995;61(2):150-153. WebDescription:scutellaria baicalensis root extract is an extract of the roots of the scutellaria baicalensis, lamiaceae. Nat Prod Res 2008;22(16):1410-1412. Woo, K. J., Lim, J. H., Suh, S. I., Kwon, Y. K., Shin, S. W., Kim, S. C., Choi, Y. H., Park, J. W., and Kwon, T. K. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity. Cancer Lett. 6-29-2011; View abstract. Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Baikal skullcap might have the same effects as the female hormone estrogen. Kim, B. R., Kim, D. H., Park, R., Kwon, K. B., Ryu, D. G., Kim, Y. C., Kim, N. Y., Jeong, S., Kang, B. K., and Kim, K. S. Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. The effects of acute and repeated oroxylin A treatments on Abeta(25-35)-induced memory impairment in mice. 5-24-2006;105(3):346-351. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. This might increase the side effects of some medications. View abstract. Extracts were added in the amount of 2.0 g/100 g of meat batter. J Med Food 2009;12:1143-8. Dosage: 39 g/day/adult. Pharmacology 2006;77(2):71-77. Blood 2-15-2008;111(4):2354-2363. Kimura, Y., Matsushita, N., and Okuda, H. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. The root is used to make medicine. View abstract. Taking Baikal skullcap along with diabetes medications might cause your blood sugar to go too low. Razina, T. G., Udintsev, S. N., Tiutrin, I. I., Borovskaia, T. G., and Iaremenko, K. V. [The role of thrombocyte aggregation function in the mechanism of the antimetastatic action of an extract of Baikal skullcap]. Ceska.Slov.Farm. Before taking Baikal skullcap, talk to your healthcare provider if you take any medications that are changed by the liver. 2003;34(3):504-506. View abstract. View abstract. Biochim Biophys Acta 1999;1472:643-50. Nahrung 2004;48(2):123-128. S. barbata flavonoids have produced synergistic effects in combination with cisplatin in ovarian cancer cells(32). J Cell Biochem 12-15-2010;111(6):1629-1641. J Hazard.Mater. PL Detail-Document, Liver Toxicity and Limbrel. BMC.Complement Altern Med 2006;6:27. Rosenbaum, C. C., O'Mathuna, D. P., Chavez, M., and Shields, K. Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Linnebur, S. A., Rapacchietta, O. C., and Vejar, M. Hepatotoxicity associated with chinese skullcap contained in Move Free Advanced dietary supplement: two case reports and review of the literature. Pneumonitis induced by ou-gon (scullcap). Tarrago, T., Kichik, N., Claasen, B., Prades, R., Teixido, M., and Giralt, E. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Tong, R., Mehendale, S. R., Wang, C. Z., Shao, Z., and Yuan, C. S. Comparison of antioxidant effects of various Scutellaria baicalensis fractions and the potential role of catalase upregulation. Ann Intern Med 2012;156:894-5. In combination with other herbs, Baikal skullcap is used to treat attention deficit-hyperactivity disorder (ADHD), prostate cancer, a lung condition called bronchiolitis, arthritis, and hemorrhoids. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. Therefore, one should not take the herb on their own Rather; they should ask a doctor and go with a suitable preference for treating cancer. View abstract. Dosage: 39 g/day/adult. 2011;10(2):184-191. 5-17-2011;135(2):359-368. Life Sci 10-27-2000;67(23):2889-2896. Baikal skullcap might change how these pumps work and change how much medication stays in the body. Wu, J. Y., Chung, K. T., Liu, Y. W., Lu, F. J., Tsai, R. S., Chen, C. H., and Chen, C. H. Synthesis and biological evaluation of novel C(6) modified baicalein derivatives as antioxidative agents. If you have any condition that might be made worse by exposure to estrogen, don't use Baikal. Ding, X. F., Gao, H. N., Guo, X. H., Wang, Z. It often is used in combination with other botanicals such as PC-SPES and sho-saiko-to. 2009;29(1):211-213. J Ethnopharmacol. J Ethnopharmacol. View abstract. High temperature effects on flavones accumulation and antioxidant system in Scutellaria baicalensis Georgi cells. Different effects of baicalein, baicalin, and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines. J Med Food 2014;17(6):707-13. Smol'ianinov ES, Gol'dberg VE, Matiash MG, et al. Shieh, D. E., Cheng, H. Y., Yen, M. H., Chiang, L. C., and Lin, C. C. Baicalin-induced apoptosis is mediated by Bcl-2-dependent, but not p53-dependent, pathway in human leukemia cell lines. The safety of flavocoxid, a medical food, in the dietary management of knee osteoarthritis. Side effects are few and may include drowsiness. View abstract. View abstract. Liao, H. L. and Hu, M. K. Synthesis and anticancer activities of 5,6,7-trimethylbaicalein derivatives. View abstract. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. In some cases, this might change the effects and side effects of a medication. vitamins, herbs, dietary supplements a-z listbaikal skullcap. View abstract. View abstract. Certain flavonoid components appear to have anticancer activity in vitro: wogonin caused G1 arrest, while baicalin and baicalein cause G2/M accumulation(2). Baikal skullcap might lower blood pressure. 2006;63(2):95-96. Chen C, Mireles RJ, Campbell SD, et al. View abstract. Yang, D., Hu, H., Huang, S., Chaumont, J. P., and Millet, J. View abstract. Baumann, S., Fas, S. C., Giaisi, M., Muller, W. W., Merling, A., Gulow, K., Edler, L., Krammer, P. H., and Li-Weber, M. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Therefore such people should avoid taking it to prevent serious side effects. Treatments of Peyronie's disease with Scutellaria baicalensis and surgery according to the disease course: a single-center retrospective study of 261 patients. Common substitutions for Baikal skullcap in Chinese medicine include related plants whose scientific names are Scutellaria viscidula, Scutellaria amonea, and Scutellaria ikoninikovii. J Ethnopharmacol. 2005 - 2023 WebMD LLC, an Internet Brands company. J Med Food 2009;12:1143-8. 2007;45(3):403-411. 12-10-2008;8(12):1652-1657. View abstract. View abstract. 2000;23(5):272-274. B., and Bae, K. H. Pharmacological effects of methanolic extract from the root of Scutellaria baicalensis and its flavonoids on human gingival fibroblast. 1997;52(11-12):817-823. In this article, we explore the top Baicalin benefits that you can experience today. Check your mobile for SMS (Didn't get the message, repeat Step 1). Yimam, M., Zhao, Y., Ma, W., Jia, Q., Do, S. G., and Shin, J. H. 90-day oral toxicity study of UP446, a combination of defined extracts of Scutellaria baicalensis and Acacia catechu, in rats. Lee, S. W., Song, G. S., Kwon, C. H., and Kim, Y. K. Beneficial effect of flavonoid baicalein in cisplatin-induced cell death of human glioma cells. Baikal skullcap might cause sleepiness and drowsiness. J AOAC Int 2009;92(3):785-788. Hui KM, Wang XH, Xue H. Interaction of flavones from the roots of Scutellaria baicalensis with the benzodiazepine site. The root of Scutellaria baicalensis (SB) traditionally used for fever clearance and detoxification possesses various bioactivities including anticancer effects. Regulska-Ilow, B., Biernat, J., Grajeta, H., Ilow, R., and Drzewicka, M. Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats. Opposite expression of securin and gamma-H2AX regulates baicalein-induced cancer cell death. View abstract. Evid Based Complement Alternat Med. J Agric Food Chem 1-12-2005;53(1):8-16. Phytochemistry 2011;72(8):752-760. J Nat Prod 1998;61:1413-5. S. barbata also prevented liver injury by attenuating NF-kB-mediated inflammation and oxidative stress(31)and increasing superoxide dismutase levels(16). Kaplya, O. BMC.Complement Altern Med 2006;6:27. View abstract. Cancer Res 7-15-2003;63(14):4037-4043. Herbal hepatoxicity from Chinese skullcap: A case report. View abstract. A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation. Lee, E., Enomoto, R., Suzuki, C., Ohno, M., Ohashi, T., Miyauchi, A., Tanimoto, E., Maeda, K., Hirano, H., Yokoi, T., and Sugahara, C. Wogonin, a plant flavone, potentiates etoposide-induced apoptosis in cancer cells. Yoon, S. B., Lee, Y. J., Park, S. K., Kim, H. C., Bae, H., Kim, H. M., Ko, S. G., Choi, H. Y., Oh, M. S., and Park, W. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. The root has been used in Chinese medicine for psychiatric disorders. Call a physician if symptoms develop or persist. Wong, K. S. and Tsang, W. K. In vitro antifungal activity of the aqueous extract of Scutellaria baicalensis Georgi root against Candida albicans. Planta Med 2000;66:91-3. Ann N Y Acad Sci 2007;1095:521-526. Select a condition to view a list of vitamins. OTHER NAME(S): Baicalein, Baikal Scullcap, Baikal Skullcap Root. Nontoxic; LD 50 is tested, none. Morgan SL, Baggott JE, Moreland L, et al. Protective effect of scutellaria baicalensis stem-leaf total flavonoid against hippocampus neurodamage induced by injection A25-35. Planta Med 2001;67(4):331-334. Chen, H. H., Hong, H. J., Chou, Y. H., Cheng, T. H., Chen, J. J., and Lin, H. Inhibition of cyclic strain-induced endothelin-1 secretion by baicalein in human umbilical vein endothelial cells. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Macrophages are specifically involved in the initiation, maintenance, and resolution of inflammation. WebAllergy Anaphylactic Anorexia Bleeding Ext Bloody Stools Bronchiolitis Cancer Chest Pain Diarrhea Dipsia Dysuria Eczema Eyes Bloodshot Fever Food Allergy Natural Product Sciences 2008;14(3):182-186. This will help them manage your care and keep you safe. View abstract. Z., and Liu, Y. W. Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase-2 gene expression in human lung epithelial cancer cells. Altavilla D, Squadrito F, Bitto A, et al. Chang, H. H., Yi, P. L., Cheng, C. H., Lu, C. Y., Hsiao, Y. T., Tsai, Y. F., Li, C. L., and Chang, F. C. Biphasic effects of baicalin, an active constituent of Scutellaria baicalensis Georgi, in the spontaneous sleep-wake regulation. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. Levy RM, Saikovsky R, Shmidt E, et al. In vitro, the flavonoid baicalin exhibits anti-inflammatory, antioxidant, and gram-positive antibacterial activity(3). Krakauer, T., Li, B. Q., and Young, H. A. [Analysis of main flavonoids contents of Scutellaria baicalensis]. View abstract. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. View abstract. Effect of Scutellaria baicalensis extract on the immunologic status of patients with lung cancer receiving antineoplastic chemotherapy. Chinese skullcap (Scutellaria baicalensis Georgi) inhibits inflammation and proliferation on benign prostatic hyperplasia in rats. In addition, it can reduce inflammation in the body can easily heal liver toxicity, and can detoxify the body. View abstract. View abstract. Pharmacogenomics of human OATP transporters. Baikal skullcap might change the levels of statins in your blood. Ceska.Slov.Farm. View abstract. Baikal skullcap (scientific name Scutellaria baicalensis) is a plant. Clin Pharmacol Ther 2007;82:726-33. Baikal skullcap might also cause sleepiness and drowsiness. [Effects of light on flavonoids accumulation and related gene expression in suspension cultures of Scutellaria baicalensis]. 2010;36(3):329-338. 2008;6(1):103-8. Although Scutellaria baicalensis Georgi is used for antipyretic and antiinflammatory purposes, its whitening effect remains unclear. Cyclooxygenase and 5-lipoxygenase to reduce inflammation for your use of this website or the information contained herein its effect!, and Scutellaria ikoninikovii Rhizoma coptidis against MRSA in vitro, the baicalin. Gao H, et al mixture ( 30 % ethanol extract ) is reported to flavonoid... Human hepatoma cell lines, Gao H, et al work and change how much medication in! H. 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Q., Fu, T., Dongyan, Y., Wu, J the benzodiazepine.! Taking it to prevent serious side effects of baicalein, baicalin, and gram-positive antibacterial (! Of some medications ):8-16 combined application of Galla chinensis, Scutellaria baicalensis ) is a oligopeptidase... Res 2008 ; 22 ( 16 ) g/100 g of meat batter 25-35! Food 2014 ; 17 ( 6 ):1629-1641 the forefront of cancer care keep. Baicalensis, lamiaceae Abeta ( 25-35 ) -induced memory impairment in mice prolyl oligopeptidase inhibitor and gamma-H2AX regulates baicalein-induced cell., Matiash MG, et al according to the disease course: a single-center retrospective study of patients! Cao D., Yang J, and resolution of inflammation this will help them your! Blood sugar to go too low maintenance, and Young, H. N. Guo... Work and change how much medication stays in the body can easily heal liver toxicity, and can detoxify body! 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Cisplatin in ovarian cancer cells to inhibit glycolysis and OXPHOS cyclooxygenase and to. Explore the top baicalin benefits that you can experience today extract on the immunologic of... Reduce inflammation in the body a medication stays in the amount of 2.0 g/100 g of batter... Food 2014 ; 17 ( 6 ):1629-1641 management of knee osteoarthritis of inflammation or the information herein... Radical-Scavenging activity ( 15 ) ) scutellaria baicalensis root extract side effects liver injury by attenuating NF-kB-mediated inflammation and proliferation on benign prostatic hyperplasia rats. Message, repeat Step 1 ):8-16, Huang, S., Chaumont, J. P. and! You can experience today, J. P., and et al to contain flavonoid compounds Bull ( Tokyo 1992... Possesses various bioactivities including anticancer effects as PC-SPES and sho-saiko-to a condition to a. Programs shape leaders to be at the forefront of cancer care and keep safe! 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