Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Beck S, Richardson A, et al. View abstract. This information should not be used to decide whether or not to take this product. Sun, Y., Chen, B., and Jia, Q. Rhubarb might harm the liver. There is a report of kidney failure in someone who took a product containing rhubarb. No adverse events were reported in the 6 trials that documented occurrences.55. The constituent aloe-emodin has demonstrated anticancer(5)(6)(27) and anti-leishmanial(30) properties, and appeared to enhance effects of sorefenib(28) and cisplatin(29). Last medically reviewed on December 23, 2021. The first reported sighting of the plant in situ was in the mountains of Bulgaria. Kidney disease: There is a chemical in rhubarb that might harm the kidneys. Patients and physicians should be aware of the potential for additive effects. Rhapontic Rhubarb Root extract, Microcrystalline Cellulose, Stearic Acid, Silica, and Sodium. You should not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. Wen et al. Researchers Marianne Heger, MD, of Health Research Services Ltd. in St. Leon-Rot, Germany, and colleagues say the rhubarb extract appeared to be safe and was well-tolerated. Recent clinical trials have consistently demonstrated its efficacy in reducing hot flashes and other menopausal symptoms, whereas investigations of other natural remedies indicate inconsistent results and ambiguous efficacy. It was no fun! Wang, Y. J., Xu, L., and Cheng, X. X. The anti-inflammatory activity of emodin may mediate rhubarbs hepatoprotective effects in rats with cholestatic hepatitis(11). Inhibition of cytochrome P450 enzymes by rhein in rat liver microsomes. You can learn more about how we ensure our content is accurate and current by reading our. A small study of an externally applied mirabilite rhubarb powder along with chemotherapy suggests symptom improvement in patients with malignant pleural effusion(42). View abstract. No evidence of any difference in effectiveness was found in 1 randomized clinical trial (N = 45) for the treatment of primary dysmenorrhea with rhubarb (1,260 mg twice daily beginning 2 days before menstruation and continued for the first 3 days of menstruation 3 cycles [2,520 mg/day]) compared to mefanamic acid (250 mg 3 times daily [750 mg/day]). Other initial studies suggest it can treat mouth sores or help reduce radiation side effects. Jin, H. M. and Jiao, D. H. [Effect of jiang-zhi jian-fei yao on gastro-intestinal movement and adipose cell of abdominal wall]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. View abstract. The constituents of R. officinale are similar to those of Chinese Rhubarb. The information contained in this website is provided for general informational purposes only. Learn about Menofit reviews here. In using this website you agree that neither Memorial Sloan Kettering nor any other party is or will be liable or otherwise responsible for any decision made or any action taken or any action not taken due to your use of any information presented at this website. Pharmacology 1976;14:48-61. This is a natural product that is going to provide you with proper support for your menopausal symptoms. Yarnell E. Rhubarb and diabetic nephropathy. A few reactions, primarily GI effects, have been reported in clinical trials. Menopause supplements: Effectiveness, side effects, and safety. Both supplements contain different ingredients: Amberen contains a blend of bioactive antioxidants or succinates, amino acids, minerals, and vitamin E. It does not contain soy, estrogen, or gluten. Like most vegetables, rhubarb offers a number of nutritional . Rhubarb is a type of laxative that might also decrease potassium in the body. Catechin, epicatechin, procyanidins, and gallylglucose were shown to inhibit hyaluronidase(10)(12). Im now 57, and its still working!! Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma. At the same time, the British East India Company secured their positions in Chinese ports. ERr 731 is a standardized extract of Siberian rhubarb root, a plant-derived, nonhormonal therapy designed to alleviate menopausal symptoms, including hot flashes. People experience menopause symptoms that range from mild to severe. Rhubarb is LIKELY SAFE when the root is consumed as food. Forsch Komplementarmed Klass Naturheilkd 2001;8:373-82. The special extract ERr 731 from the roots of rhapontic rhubarb has been regularly prescribed for women with menopausal symptoms since 1993. Please read the full product reviews disclaimer. This product may be unsafe when used before surgery or other medical procedures. To obtain high-quality planting material for the value selection of the rhubarb 'Raspberry', we evaluated the morphological and physiological responses of micropropagated plantlets to . Diarrhea can increase the effects of warfarin and increase the risk of bleeding. Some research has shown that compounds found in the stems of rhubarb can help improve blood sugar levels and even lower cholesterol. Sandy, OR: Eclectic Medical Publ, 1997. 1993;40(2):111-116. Clinical study on effect of shenlong oral liquid combined with radiotherapy in treating nasopharyngeal carcinoma. Anticancer effect of aloe-emodin on cervical cancer cells involves G2/M arrest and induction of differentiation. Relief of all Major Menopause Symptoms. The herb was brought from the eastern Mediterranean by way of the Silk Road, which stretches from China across central Asia. The chemistry and biological activity of herbs use in Flor-essence herbal tonic and Essiac. J.Tradit Chin Med 1980;21(11):18. The three primary ingredients of Estroven include black cohosh, soy isoflavones, and rhapontic rhubarb extract. View abstract. Short-term treatment with a rhubarb navel plaster improved bowel function in patients with chronic constipation . Zhong.Xi.Yi.Jie.He.Za Zhi. You can take these products together and they are available at health food stores and online. Studies in humans are limited, but suggest rhubarb can improve feeding tolerance and relieve gastrointestinal dysfunction in very ill patients. Estrovera is from a reputable manufacturer Metagenics, which offers a wide range of products. Influences of processed rhubarbs on the activities of four CYP isozymes and the metabolism of saxagliptin in rats based on probe cocktail and pharmacokinetics approaches. It is interesting to note that the hot flashes continue to decrease in frequency I have had hot flashes for the last 8 years. A Study has proved the favorable effects of stearic acid[3]. Decreasing how much medicine your body absorbs can decrease the effectiveness of your medication. The actual details of how it does so are not found on the products. It appears to have some benefits for the . extract significantly improved symptoms as compared to placebo. I didnt even recognize myself. Positive reviews mention that the supplement reduced menopause symptoms. The edible stalks are up to 45 cm long and 2.5 to 5 cm in diameter, and are used in pies, jams, jellies, sauces, and juices.1, 2, Medicinal rhubarb consists of the dried rhizome and root of R. officinale Baillon or R. palmatum, of related species/hybrids grown in China (Chinese rhubarb), or of Rheum emodi or Rheum webbianum native to India, Pakistan, or Nepal (Indian rhubarb).3, Rhubarb was first recorded and rated as one of the inferior remedies in the oldest Chinese herbal books, from 22 to 250 AD.4 In the 1780s, the active constituents responsible for the root's cathartic action and astringency were still unknown. Effects of rhubarb extract on radiation induced lung toxicity via decreasing transforming growth factor-beta-1 and interleukin-6 in lung cancer patients treated with radiotherapy. Many Estroven products contain soy, but the Complete Menopause Relief supplement does not. It claims this product relieves 10 symptoms of perimenopause. Jiao D, Shen X, Gao Y, and et al. Neither products have FDA approval, and there is limited research on their effectiveness or safety. It is also a component of Essiac tea. . 2 Improvements were . Your email address will not be published. Research and studies on both products are limited: A 2019 study split people experiencing menopause symptoms into two groups. The feedback form on this page can be used to report content that is not accurate, up-to-date or questionable in any manner. Its manufacturers claim that it can help people experiencing menopause. Ma, L. [Experimental study on the immunomodulatory effects of rhubarb]. Other studies suggest it may improve feeding tolerance and relieve gastrointestinal dysfunction in critically ill patients(23) or help prevent procedure-related pancreatitis and hyperamylasemia in high-risk patients(24). German doctors have been using Estrovera to help their menopausal patients for 20 years. PMID: 20170496; PMCID: PMC2837008. A review. In most Western countries, hot flashes affect up to 80% of menopausal women. 2023 Healthline Media UK Ltd, Brighton, UK. Chinese Journal of Nursing 1995;7(30):420-422. Zhong.Xi.Yi.Jie.He.Za Zhi. Rhubarb is also used as a flavoring agent. 2010 Feb 19;5:7. doi: 10.1186/1749-8546-5-7. View abstract. It also has additional products that target specific symptoms. View abstract. Part 182 -- Substances Generally Recognized As Safe. Zhong.Xi.Yi.Jie.He.Za Zhi. Common side effects may include: stomach pain or upset; heavy feeling; vaginal bleeding or spotting; . Nutrition. Pharmacology 1980;20 Suppl 1:128-30. Sun, D. A. You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. It is created by eHealthMe based on reports of 163 people who have side effects while taking Rhubarb from the FDA, and is updated regularly. Results of double-blind, randomised, controlled clinical trials]. Goel, V., Cheema, S. K., Agellon, L. B., Ooraikul, B., and Basu, T. K. Dietary rhubarb (Rheum rhaponticum) stalk fibre stimulates cholesterol 7 alpha-hydroxylase gene expression and bile acid excretion in cholesterol-fed C57BL/6J mice. Your results can and will vary. Other prescription drugs such as antifungal medications, blood thinners, cancer treatments, and heart disease medications can also result in adverse reactions when taken with rhubarb. Liver problems: Rhubarb can make liver function worse in people who already have liver problems. Zhonghua Yi.Xue.Za Zhi. (Chinese Journal of Modern Developments in Traditional Medicine) 1985;5(6):382-384. They say the results suggest ERr 731 may be a viable alternative treatment for women experiencing severe hot flashes associated with menopause and perimenopause. There do not appear to be any studies that directly examine the effectiveness of Estroven. Standardized rhapontic rhubarb extract (also called "false rhubarb" or "Siberian rhubarb") is easily found in a handful of supplements - usually marketed as "menopause relief" blends - here at home. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. I was in full swing menopause and I was pretty miserable. Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings). Rhubarb is a plant. [Clinical evaluation of crude rhubarb powder and cimetidine in upper gastrointestinal bleeding]. TCM doctors use rhubarb root to treat constipation, high fever, abdominal distension, gall stones, jaundice and, surprisingly, acute dysentery, due to the herb's anti-bacterial activity. My doctor recommended this product. View abstract. The information contained in this website is provided for general informational purposes only. Disclosure of Material connection: Some of the links in the post above are "associate sales links." Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. The quality and quantity of rhubarb crops are significantly dependent on planting material. Zhong.Xi.Yi.Jie.He.Xue.Bao. Odenthal, K. P. and Ziegler, D. In vitro effects of anthraquinones on rat intestine and uterus. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. Br J Pharmacol 2001;134(1):11-20. Further a recent preclinical study excluded unwanted side effects on Is rhubarb anti-inflammatory? View abstract. Arch Oral Biol 4-5-2006; View abstract. Zhang, J. H., Li, L. S., and Zhang, M. Clinical effects of rheum and captopril on preventing progression of chronic renal failure. A: The product is not to be used by women who are currently pregnant or nursing. It is a strong cathartic and is thought to increase the excretion of waste products, including nitrogenous waste accumulated in patients with renal failure, through the intestines. Zhong.Xi.Yi.Jie.He.Za Zhi. In some people, rhubarb can cause diarrhea. Int J Food Sci Nutr. Li, T. [Rhubarb in the treatment of viral hepatitis and its mechanism of action]. Evidence for safety and efficacy in humans is limited. Other websites claim that the key ingredient helps fill in the estrogen deficit during menopause which is the primary cause of menopausal symptoms. The following are some of the common side effects of this herb. Animal studies suggest the potential for liver toxicity at high doses and with long-term use(40). Rhubarb refers to a plant species in the Rheum family with roots in India, China, Turkey, and Iran. In addition, rhubarb roots and rhizome, if taken in the form of medicine in the right dosage for four weeks, is still possibly safe. Below is a comparison chart with key information about Amberen and Estroven supplements. [Observation on therapeutic effect of Rhubarb and sanchi powder in treating patients with hemorrhagic fever in nephrotic syndrome complicated with digestive tract bleeding]. Also, the product comes with a money-back guarantee which allows anyone to test if the product is effective for them or not. View abstract. View abstract. The root of Siberian rhubarb is rich in hydroxystilbene . Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials.". However, their Amazon customer rating is 4.3 out of 5 stars. Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones. Xiao-dong Z, An-yu W, Shao-feng W, and et al. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. Vegetable stearic acid is going to enhance your energy levels and it is going to improve your overall health condition. View abstract. [Clinical study on effect of Chinese herbal medicine combined with hemodialysis in treating uremia]. However, there are many clinical studies with details available on the menopause support website proving the effectiveness and safety of the only active ingredient in providing relief to symptoms of menopause. Active Ingredients:Rhapontic Rhubarb Root Extract, Microcrystalline cellulose,, dicalcium phosphate, stearic acid, croscarmellose sodium, magnesium stearate Estroven Complete Menopause Relief Pros & Cons Pros May relief up to 12 symptoms of menopause by up to 60% according to the manufacturer Observation of therapeutic effect in 50 cases of chronic renal failure treated with rhubarb and adjuvant drugs. Albrecht UW. 1-30-1992;62(596):23-25. Rhubarb is considered to be a stimulant laxative. Shanxi Journal of Nursing 1997;11(6):262-263. The efficacy of ERr 731 , a commercially available extract isolated from Rheum rhaponticum, in terms of menopausal complaints like hot flushes, depression, anxiety and vaginal dryness has been proven in a two-year clinical study.Further a recent preclinical study excluded unwanted side effects on the endometrium by showing a lack of stimulation of proliferation marker genes by ERr 731 or . A meta-analysis suggests that rhubarb adjuvant to early enteral nutrition may benefit patients with severe acute pancreatitis(35), but a systematic review does not support its use for gastrointestinal failure in ICU patients(36). Initially, researchers learned that the medicinal root came from several varieties or species of rhubarb. Traditional Chinese medicine suggests rhubarb improves the memory in senile patients.37 In in vitro experiments, rhapontigenin exerted a dose-dependent protective effect on mitochondrial functioning against amyloid beta (1-42) neurotoxicity.8 Clinical trials are lacking. Design: Three hundred sixty-three menopausal women with menopausal . a plant-based extract of Siberian rhubarb. Planta Med 1995;61(5):425-428. They dont seem to be thoroughly supported by the ingredients and the working process of the product. 2004;24(12):1084-1086. Menofit is a probiotic supplement. The leaves are heart-shaped at the base with five prominent nerves. Note: Results may vary about any product effectiveness. A: Take one tablet with nourishment and a glass of water once every day in the meantime of the day or as coordinated by your human services professional. [Chinese Journal of Integrated Traditional and Western Medicine] 1986;6(8):458-459, 451. Some laxatives can decrease potassium in the body. Dosing. Wang, Z., Wang, G., Xu, H., and Wang, P. [Anti-herpes virus action of ethanol-extract from the root and rhizome of Rheum officinale Baill.]. $29.99 for 30 capsules. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(11):655-7, 643. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Below is a comparison chart with key information about Amberen and Estroven supplements. Patients and physicians should be aware of the potential for additive effects. Matsuda, H., Morikawa, T., Toguchida, I., Park, J. Y., Harima, S., and Yoshikawa, M. Antioxidant constituents from rhubarb: structural requirements of stilbenes for the activity and structures of two new anthraquinone glucosides. Disclaimer: The information provided on this site is intended for your general knowledge only and is not a substitute for professional medical advice or treatment for specific medical conditions. Rhapontic Rhubarb Root extract - This is a natural product that is going to provide you with proper support for your menopausal symptoms. The Complete Menopause Relief treatment is vegan-friendly and gluten-free. These products include Stress Relief & Energy Boost, Weight Management, and Sleep Cool. Rhubarb is a laxative. Toxicity 9/8/201932 Young rhubarb flowers Rhubarb leaves contain poisonous substances, including oxalic acid, which is a nephrotoxic and corrosive . Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. 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