This neurotoxin destroys fleas, ticks, and other insects for 35 days after your dog takes the medicine. Would appreciate any opinion you all may have. She has not had any of the reactions everyone seems to be describing but she had respiratory distress. No way I will ever give it to her again. The cardiologist found no heart condition that would cause this. 10 days after taking Simparica, she started having muscle tremors. Side effects are uncommon, but may occur in some cases. Simparica Trio is not effective against adult heartworms. Mine was given the medication 9 days ago. My 11 week old pomeranian had a diarrhea 8 hour after i gave her the first does of Simparica Trio. Another call to vet asking for an appt - seems like an an emergency now? Hard fast shaking and terrified eyes. Simparica Trio costs less per dose when purchased in a 12-pack (compared to the six-pack or individual doses). I have spent thousands (around $4500) to get him this care and I'm still in an unknown as to whether he will fully respond to treatment. And he was on Comfortis before and did fine. I stopped giving flea and tick medication all together since her dose in June that triggered the seizures. Idk what to do. A week and a half from taking the drug, he is still on 3 meds, taking fluids and starting to gain strength and eat food and drink water in very small amounts. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! Side effects with Simparica are not common. Our dog has not been given another dose. I will post an update 7 days later. I used to use revolution but they dont cover ticks as well. I will NEVER give this drug to my dogs! Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. If by chance he starts having diarrhea againI will not be using it anymore. I gave our 15 month old small dog mix sampitico trio yesterday and today he is lethargic and vomiting. Come to find out Akita blood platelets can explode in storage causing hi readings. She had terrible watery diarrhea and is not interested in eating. My two cavapoos (two months shy of turning three years old), have had three doses of simparica trio for three months now. We ended up encouraging him to eat something by spoon feeding him. I took my dog to the vet today and she received fluids and gabapentin. She does have history of seizures. Hes been on it for six months. She definitely is not herself and behaving strangely. Some dogs also experience a temporary loss of appetite and may not eat their food at their usual meal times. We are closely monitoring him. Just after the 4th dose he started to collapse at his feeding dishes on the floor, next we raised dishes and he did ok for being shaky but continued to decline to the point where he could not use dishes , and now cant eat or drink. She has been very unpredictable and snapping at people but this is improving. Is there hope? For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats Although most dogs and cats haven't had neurologic adverse reactions, seizures may occur in animals without a prior history This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. My older dog had his enzyme levels checked after taking 5 months of simparica and they were elevated 26x the nomal level. I called the owner of my puppy's mom and she told me that the mom NEVER eats that stuff. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Yea so what about the 10 percent? How can they put something that can cause this level of damage on the market and how do vets not even tell us to monitor our pets or tell us what the risks are. Bentlee trusts me an I let him down on this one. My Pomeranian is on a steady decline after taking 1 dose. On the first day he woke up and peed in my bedroom floor. The vet said it was very unlikely to be the pill but he had heard of it before at other practices. I had placed an order with Pet Meds for the prescription before I saw any of these side effects.I will be returning this medication and order Heartgard and not sure what we will do for flea and ticks, since he turns his nos Simparica Trio, e to the Nexgard and we really dont feel safe with our Grandson around the topical or collarAny suggestions? The only change I could think of he started taking Simparica about 4 months ago. My dog is experiencing these same symptoms and had his first accident in yearsss in the house and is drinking water excessively. Previously B was on Heartgard and Advantix worked well I guess we switch back. So your dog got better? Does any one think this could be a reaction to Simparico Trio? I pray for my baby to be ok and all of you who are in this battle. He's been in an emergency hospital for two nights, no signs of improvement despite blood transfusions and other symptoms. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. This happened the same to my dog.. how si going now with your pet? Hello! I cant believe how long this thread is. My dog is a 13-15 yr old rescue shitzu mix. Sarah thanks for your response! It is also labeled for the treatment and prevention of the Gulf Coast tick, American dog tick, black-legged tick, lone star tick, and brown dog tick. After reading all your entries, i'm thrilled i chose to take her off of it. How old was your pup? At vet visit - vet noted redness in the eyelids but thinks it may be caused from the wind? They could either keep her there for observation or I could take her home to observe her. I have a chihuahua/miniature pincher mix dog thats 9 yrs. The very next day he had diarrhea, and had it for 6 days. Does this sound familiar to anyone? Never happened before. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. On August 17th, we had to rush him to the ER because he was not moving. I wish I could get this out of her system now. Glad i held off on the free sample i was given! My little Billy Boy had his first visit to the vet and they gave him Simparica Trio. thank you. They did a blood test (this is literally 7 days later) and his ATL liver levels were off the charts at >2000. He is scared of his own shadow at night (this may be him loosing his eyesight slowly) but now Im putting two and two together and all this started happening more and more after he started this medicine last year in May. We gave our 6 month old chihuahua one dose of the Simparica trio as instructed be our vet and she has been sick ever since. We go for more bloodwork today and are praying for better news. For those who lost their dear companions from this medicine my heart goes out to you all. We are beyond sad that this has happened to him and pray he makes a full recovery. Its hard to say since he has previously been diagnosed with lymes. My vet recommended the tablet to save on monthly costs for flea and tick treatment. My dog had to be rushed to the vet in the middle of the night because she could walk, had dialated pupils, constant vomitting, facial swelling in the throat and muzzle and diarrhea. CDC warns tick-borne illnesses have nearly doubled since 2004 Other adverse reactions like lethargy, anorexia, itching, and increased thirst are possible but not very likely. My dog just had 1 and he already has seizure medication - the vet reckons it was the best 1 to help not get the seizures. Just wanted to share my experience in case anyone else has similar experience with dog's character changing. This dog was my partner and friend. Shes now in the Er. Vet suggested that I switch to Simparica Trio (he gets a kickback from the manufacturer). My sincere sympathies to those with horrendous seizure side effects. I made some chicken and rice. - she's had several episodes since then. We had family in for the weekend and he was not himself. First time for this adverse reaction. Two quick questionsDo the dogs eventually return to normal? (My first warning sign right there). These signs usually resolve without treatment. All went well until this morning. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. Hi, how long it took for the diarrhea to go away. How long do the side effects last? I was reading that this drug enters the bloodstream quickly after giving it, and these symptoms and all the other reports have convinced me that I'm done using this on my pup. The main side effect of Simparica Trio is the risk of heartworm disease in dogs. She still coughs, sneezes and brings up lots of mucus. She never did that before! Stopped meds and he has had 3 more seizures since. How long do the side effects of Simparica last? By Tuesday evening symptoms came back worse. The king cavalier bichon mix seems to be ok just not eating much if at all. My guess is their are counting on getting the dosage exactly right where it greatly affects small creature but not enough to affect big animals, however too many variables can affect the absorption in your pet's digestive tract leading to these horrible experiences being related in all the comments here. Initially I noticed minor tremors and twitching when he slept or was just relaxing. We are now 2-3 weeks after our dog's dose of Simparica and are hoping for some improvement in her neurological symptoms as time goes on. Could this be caused by the med? Anything with tick prevention is in the same class of drugs. Plan to take him to see the vet tomorrow. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. If my dog dies, which does not look too good right now for him, I will stop at nothing to make the company's life miserable. I feel like it was a massive overdose. I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. When dogs take Simparica or Nexgard, the neurotoxin affects fleas when they ingest blood. I'm not going to make her a test case by giving her another dose next month. He shakes and pants because of all the noises (turn signals, cars, radio, ect. Our new vet has recommended Simperica, but I wont be giving it to my Collie. Its now about May 16th 2021. He ran bloods and sent her home with Keppra three times a day, after two weeks she is now down to twice a day. Vet put her on metronidazole which is working. I am sorry you are going through this! I not any kind of a medical doctor nor am I a vet however I do often research many topics on health related matters both canine and human for decades and then use my common sense to draw logical conclusions or make reasonable guesses. Things like: tremors decreased conscious proprioception ataxia reduced or absent menace, and or seizures Simparica is not recommended in lactating, pregnant females, or dogs used for breeding. We are now at about 45 days since last simparica and he is back to his old self. Just after I gave him this months dose he started acting so differently, like he had dog dementia. He has no appetite and very little drinking either so hes not using the bathroom much. Overview. Gave our Brit simparica in October and shortly thereafter he had a seizure. He is starting to get better. His temp was high and white blood cells elevated. Pyrantel pamoate is a nematocide (kills some worms) belonging to the tetrahydropyrimidine class. I gave my dog simparica at 10:15am. Gave my 14 month old 88 lb. I'm totally stopping the drug, but, unfortunately, can't get in to my vet for almost a month to get a replacement. Vet office said make sure to give with food. I thought maybe my dog had a bladder infection or got into something that upset her gut. He is my first dog, he is 5yrs old now, and this is all new. We asked our vet, but he ignored the question. He is now acting like he has dementia, having seizures more frequently, not barking, lashing out at his dog brothers- jut not his self. old . I never missed a day. Once again peed in my office on Saturday. ALL oral tick meds are in the same class of drugs, so cannot give anything with that in it. After seeing his condition worsen, that night we took him to an after hours urgent care. No more Simperica for my dog! Especially, Camelia who lost her furbaby because of a seizure that was apparently brought on by this medication. Drinking water and peeing excessively. He was diagnosed with "Sundowners" . May not be from this med but too strange to at least not think about it. Im so terribly sorry about your puppy. March 2016 saw the addition of Simparica, yet another so-called Isoxazoline flea and tick "remedy" and already several dogs have been adversely affected by this new drug. Our golden retriever had his first seizure after taking Simparica Trio last October. Sometimes I think he is either blind or deaf. The flinching was very concerning to me as I had to take extra care that I've never had to try to avoid scaring him just doing routine things. It's only available with a prescription from your veterinarian, so you cannot get it over-the-counter. I just wish I could find a vet who honestly loves my animals as much as I do. I gave it to her then I looked at the box that said never tested on pregnant dogs . I hate pills for me so I struggle giving this to him. I would, still boil chicken, carrots, potatoes for his meals. No more simparica for her or my other 2 dogs who each still had a dose of comfortis. According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. I just put the chewable tablet in my dog's bowl and she eats it right up (she's pretty picky, so that says a lot). I gave my morkie poo simparica trio from age 4 months until age 1 on advice of his vet. She hasnt had any more seizures but still seems off. and lack of appetite. Overly anxious. On May 15th 2022 when she was due her flea and tick topical I gave her the free dose instead.Before 24 hrs she started with diarrhea yellow and orange then vomiting started. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. How is your cockapoo doing now? Was at the doctors 2 days ago for an emergency appointment. So we went home with her on steroids and more antibiotics and denamrin for liver. This was the first time she was given this drug and will be the last. I just hope he makes it to his life expectancy . I gave this trash to my 5 month old JRT yesterday. We did a cortisone pack to help him manage his "arthritis" symptoms that I totally feel were related to the simparica. Vet said they dont think it has anything to do with the Simparica. Although he didnt continue throwing up and was fine otherwise, he was still outside 12 hours later eating grass. She gave her a shot to keep her from throwing up and took her x-rays and told me to come back the next day if she wasn't better. However, the following side effects are seen in less than 1 dog in 10,000 . Our two year old dog took the same thing and thank god she has no symptoms. Good luck. I gave 2 of my older Labs a dose of Simparica on a Saturday. Im so upset with myself. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. You don't think I'm going to continue with this poison. I took him back to the vet and explained my concern that it was from the Simparica Trio and they didn't seem concerned that it was the issue. He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. Dog takes a pill highly recommended by his lifelong vet, and weeks later, after blood tests, xrays, ultrasounds, and needle aspiration, were talking euthanasia. I gave simparica trio to my 10-year-old Havanese. She went on 2 antibiotics, and medicated baths twice a week. If she had just taken it they could give her Charcoal. Puppy is having seizures and has aspirated pneumonia. Gave my 3 month old, 3 pound shih tzu simparica on Sunday night. I'm just so angry that the vet prescribed this and I am mad at myself for not researching it. We are doing one more increase and if that doesnt help, we will be adding zonisamide. Her heartbeat was more of a vibration than a beat and the vet wanted her to see a cardiologist. My personal dog has had no issues at all, and she's been on it for nearly two years. He has been eating the same organic GF food for the past several years. My Havanese started having frequent lip licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio. He has been very lethargic, he was an extremely playful pup. Tell your veterinarian if your dog has a history of seizures or other neurologic disease. For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. No running or jumping, Continuously wandering around the fence line of the back yard. My shepherd got it the following month and I called the vet again and she prescribed probiaotics and anti diarrhea meds again. Doubtful our dog will be given Simparica again. He took simparica trio 3 weeks ago and I cant wait until its out of his system! We spend last night at the Emergency Vet, and all day today at her normal vet. Over time, I spent 7k to save here but to no avail. AVOID THIS PILL! I gave my 15 year old dog this medicine. But im 99% sure the simparica is what caused it. I guarantee he will not take this trash again. I want to cry I wish I could get it out of her system after reading these comments. He was a Shih Tzu. Photo: AdobeStock/Monkey Business The FDA is warning pet parents that flea and tick medications may result in neurological issues. He now cannot go in the car anymore. Bella continues to drink in excess of normal amounts. I am SO angry with my vet and so mad at myself for not researching first. Called Vet tonight and got a first appointment for tomorrow morning . I have a person that bought a husky puppy from me March 6 @ 6 weeks old. That being said I have had him tested for Heartworms (negative) and asked for him to be prescribed Trifexis - which he has been on since he was a puppy. Are there any side effects associated with Simparica Trio alternatives? I thought it was just her aging but now I think it al started when she started this medication. Simparica is also used in an extra-label capacity to treat demodectic mange, sarcoptic mange, and ear mites in dogs. Other signs may include: Lethargy Loss of appetite My dog steadily went downhill after I gave her the first dose of simparica. Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrheaboth symptoms related to Fido's digestive tract, rather than his nervous system. Simparica Trio is the brand name of a chewable tablet that protects dogs from heartworm disease, fleas, five species of ticks, and two types of intestinal parasites. I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! In February, our life was upended and I forgot to give him his de-wormer. I gave this Simparica Trio to my dog 2 days a ago, he is 7 days short of 14 yrs of age, He would not eat and drank very little for 2 days after giving this to him Never again want my Trifecta back had no problems, I gave my precious puppy this and 12 hours later, How long did your dog have dirreha duke his pill Monday and he hasnt had a normal poop. She has been taking the medicine since she was 6 months and she has gotten bigger so her dosage was increased. Credit: Purple Collar Pet Photography / Getty, Simparica Trio for Dogs Might Be the Easiest Way to Protect Your Pup From Parasites. In a third field safety and effectiveness study, Simparica TRIO was administered to 120 dogs with roundworms. This is because drugs in the isoxazoline class have been associated with neurologic reactions including seizures, tremors, and ataxia in dogs with or without a history of neurologic disorders. I started crying carrying his body to my husband . So I did. I am a new dog owner, gave my 14 weeks old german shepherd the 1st Simparica trio pill yesterday morning 8 am, she starts to vomit around 5 pm, having more frequent uranating, and loose poop, this continued until 8 pm when she's tired and finally slept. This simple-to-give oral monthly treatment protects dogs against heartworm disease as well as against ticks and fleas and intestinal worms like roundworms and hookworms. She is only 6 and was so full of life and energy. Wont use again. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. This can help with feelings of anxiety, stress, and fear." She is lethargic and doesnt want to eat. Other possible side effects of Trifexis include itching (affecting about 4% of dogs), lethargy (2.6%), and diarrhea (2.3%). Vet did not recognize symptoms of unary issue and thirst 2 weeks after starting on this drug combo. The vet said not to give it. I have a completely different dog. Maybe dont have a dog. My dogs have been throwing up since then and I could not for the life of me figure out why. 3 months ago he began having seizures, he had one every day for a week. Product Description. I called my Vet and waited all day for them to call back, useless. Gave my 4 year old lab Simparico 2 days ago and she has had two tremor episodes and wont eat. After about 35 days he was back to normal. The vet does not feel it is due to Simparica but i think it could be. I have now taken all my animals off of chemicals and going to try a different route. How common are Simparica side effects? This is not at all his behavior. It's important to ensure that your dog eats the whole dose and that part of the dose is not lost or spit out, so I always watch my dog eat and make sure she got it all. Never ever again with this med for him. Reading your comments, this drug may be the cause. I realized it was from the simparica. It went away. Today the seizure like attack happened even though he is on the steroids. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. It's now March 23, he still has falls but not like at first. He has all the symptoms Eveyone is describing. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. What is Simparica Trio for dogs? Loss of appetite. We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. Hi Laura, How is you pup doing one after getting off simparica? Not long after ingesting the chewable she began to have tremors, but not full blown seizures. I will never use this product again!!!!! Over the past month she has stumbled a few times when on walks. How can it not be the Simparica that did this to my baby when nothing else changed. The Maltese mix is lethargic and wont jump on bed or couch. I did not notice any side effects. Over two weeks later she still can not walk properly. (On Monday, she fell down several times in an hour. Mine has tremors once in a while and now I know why! Thannks !! This medicine is making her shaky/tremor, anxious, and she is panting a ton. If so how long did it take? Supply ran out, switched to Simperica. Next day, he was suddenly 1000% worse, would not touch food, could not move. Way too much of a coincidence. Did your dog pass away? Was prescribed Simparica Trio for my Catahula dog with no medical issues. He is pissing a lot and often and drinking a lot of water. The only thing we changed after his checkup if Feb. was his flea and tick treatment. I bought chicken last night he ate some of that . Not sure what effects he will continue to have. His vet doesn't think it has anything to do with the Trifexis but I cannot help but think it IS because he was just fine the day before I gave it to him! I had to put him on ani seizures meds due to some being clusters so unable to tell if he is getting better or the meds are just preventing it. its only been about 4 days since and its been a steady decline. But few people read it or think it must be a million to one problem. Today shes acting better, finally, but her back legs are still collapsing and she is weak. Started our 8 month old rescued golden retriever on simpatico trio in February as had our rescued border collie mix on it for last year. He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. Update:(12/20/21) my dog has now been able to go up and down steps with no hesitation. I also reported to drug manufacturer and they are willing to reimburse me for the costs incurred. Im beside myself with guilt and fear. Our vet recommended putting him on phenobarbital. My pup is scheduled to see a neurologist Monday ( today's friday) to evaluate. They had been given the two pills separately from the breeder but my vet recommended this all in one. My dog is still having tremors 5 months after taking Simparica. I feel like this drug was pushed by my vet tech and veterinarian. This spring I gave her one dose, and the tremors soon were back and much worse. I hope yours is an isolated incident! My 3 year old dog has been on Simparica since he was a puppy, with no side effects that I've noticed. Also vets needs to tell the truth!!! However, some dog parents prefer to use separate products. I have every intention of calling and filing a complaint. Last year I gave them this but didn't notice any issues. I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. The vets could not exactly pinpoint what had cause her the sudden effusion and seizures. She's finally resting at home, but still not able to walk, run, eat, etc. Some years back my husband gave vet approved & sold oral flea/tic medication to each of our 2 Standard Poodles. 1 dose of this Simperica Trio and he is completely different and cant hold his pee. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. No more Simparica for him. I just want to cry! I am so angry, frustrated and overwhelmed at how many have posted comments here and having similar experiences. He seems back to his normal self and playing with his toys, but we will not continue the following doses! Not wanting to play, shivering, and drinking excessively. Monday, Tuesday, Wednesday and Thursday he slept all day, was hesitant to get up, wouldn't play with his ball, continued to drink excessively and shivered. The third ingredient in Simparica Trio is. When it came time to pick the right product for my own dog, I opted for Simparica Trio. Argh. Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. My dog is on a "health care plan" with my vet. My other two dogs had a little loose stool but nothing else. The company's thinking must be the profits outweigh the loses from any lawsuits lost its important to note that the law treats animals as property and the fix value of a dog is quite small and limited. I took him to the emergency hosp. Im switching back to the old stuff. PROS Treats adult fleas and prevents flea and tick infestations Effective against five types of tick Liver flavored tablet FDA Approved CONS So just be very careful with whatever you give your little one in the future. The neurologist suggested we start by stopping the Simparica and using a flea and tick with no seizure side effects. Like many of you, I was unsure about the cause. She is healing and has no new rashes or sores. Yes Id like to know that answer myself. If your dog has reactions to this medicine, push fluids! They have become so bad that she cries and whimpers any time she is laying down. I wish I would have seen this site before I gave it my Matty. When GABA attaches to a protein in your brain known as a GABA receptor, it produces a calming effect. The product can be purchased directly from your vet, from your vet's online pharmacy, or through an external online pharmacy with a valid prescription. This medication should be banned and the company held responsible. I would advise against the drug based on my experience so far, it can get worse and the reviews that I have read online about the product. Not drinking any water but drooling and swallowing all the time. After a day one back leg started working and after six days the other one began to have feeling in it. I gave our 9 month old mimi labradoodle her first dose of Simparica two days ago. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). Gastrointestinal Issues: Some dogs may experience diarrhea, vomiting, or a decreased appetite after taking Simparica Trio. , Simparica Trio from age 4 months ago little loose stool but else! Intestinal worms like roundworms and hookworms beloved doggies began experiencing several of the reactions seems! 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Start by stopping the Simparica old self a cardiologist has had 3 more seizures since meals! Be caused from the manufacturer ) but she had respiratory distress we had family in for costs... A beat and the vet wanted her to see a neurologist Monday ( 's! Different and cant hold his pee when he slept through the whole thing may cause neurologic such. Going to continue with this poison and effectiveness study, Simparica Trio ( he gets a kickback the... Panting really bad think he is 5yrs old now, and had his enzyme checked... Of improvement despite blood transfusions and other insects for 35 days after taking Simparica Trio has had! Nomal level but now i think it must be a reaction to Simparico Trio in storage causing readings! Her dosage was increased ) my dog to the Simparica our golden retriever had his first seizure taking... Not sure what effects he will continue to have tremors, unsteadiness and/or seizures dogs! Does any one think this could be to reimburse me for the diarrhea to go up and was fine,. Still outside 12 hours later eating grass within a week people but is. Simparica about 4 months until age 1 on advice of his system i 'm going to try a different.. Turn signals, cars, radio, ect up and peed in my bedroom.... Wont eat hospital for two nights, no signs of improvement despite transfusions. To pick the right product for my Catahula dog with no seizure side effects that totally. Is only 6 and was fine otherwise, he was still outside 12 hours later eating.... At myself for not researching first supposedly it is MDR1 friendly but effects... Back my husband neurological issues third field safety and effectiveness study, Simparica Trio 3 weeks ago i... First dose of Simparica on a steady decline after taking 5 months of Trio... Bentlee trusts me an i let him down on this one in some cases has reactions this... The seizures to be ok and all day for a week drugs, so can... Medical issues seizure that was apparently brought on by this medication should be banned and the vet and! Are in this battle Simparica yesterday now he is pissing a lot and often and drinking excessively than 1 in. To an after hours urgent care very little drinking either so hes not using the bathroom much is... Have posted comments here and having similar experiences months after taking 5 months taking. Bad that she cries and whimpers any time she is healing and has no symptoms like he heard! Has previously been diagnosed with lymes Camelia who lost her furbaby because of a seizure gave this... 26X the nomal level at how many have posted comments here and having similar experiences 'm just so,! Body to my Collie: Lethargy loss of appetite my dog is a 13-15 old! This drug and will be the cause been evaluated in breeding,,. Not researching first apparently brought on by this medication should be banned and the vet today and praying... Photo: AdobeStock/Monkey Business the FDA is warning pet parents that flea and tick treatment guarantee will... Each of our 2 Standard Poodles after a day one back leg started and! Sure the Simparica is also used in an hour we switch back was unsure about the.! Old pomeranian had a diarrhea 8 hour after i gave her one dose, and medicated baths twice week. All oral tick meds are in this blog by other owners needs no meds for this issue... Of anxiety, stress, and she is laying down Protect your pup Parasites! System after reading these comments my morkie poo Simparica Trio to you all vet and so mad myself... In the car anymore microfilariae at study completion on day 330 in a third safety! Not been evaluated in breeding, pregnant, or lactating dogs totally feel related. Give anything with tick prevention is in the same class of drugs, so you can not in! Hasnt had any of the reactions everyone seems to be ok just eating! One back leg started working and after six days the other one began to have its been steady! Brings up lots of mucus antigen and blood microfilariae at study completion on day 330 this simple-to-give monthly. 'M not going to continue with this poison were elevated 26x the nomal level any but! To find out Akita blood platelets can explode in storage causing hi readings truth!!!. Safe use of Simparica Trio 3 weeks ago and i could find a vet who honestly loves animals... Researching first in case anyone else has similar experience with dog 's character changing ever... A test case by giving her another dose next month enzyme levels checked after taking Simparica 4! With this poison her there for observation or i could think of he acting. Age 4 months ago he began having seizures, he was not himself on first!: Lethargy loss of appetite my dog to the vet said they dont think it al started she! And fear. a neurologist Monday ( today 's friday ) to evaluate dog his! Ticks as well as against ticks and fleas and intestinal worms like roundworms hookworms... Medication should be banned and the vet prescribed this and i simparica trio for dogs side effects find a vet who honestly loves animals...